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Jiafu Wang Selected Research

Pain (Aches)

1/2023Bipartite Activation of Sensory Neurons by a TRPA1 Agonist Allyl Isothiocyanate Is Reflected by Complex Ca2+ Influx and CGRP Release Patterns: Enhancement by NGF and Inhibition with VAMP and SNAP-25 Cleaving Botulinum Neurotoxins.
1/2023Myeloid Vamp3 deletion attenuates CFA-induced inflammation and pain in mice via ameliorating macrophage infiltration and inflammatory cytokine production.
8/2021Selective Expression of a SNARE-Cleaving Protease in Peripheral Sensory Neurons Attenuates Pain-Related Gene Transcription and Neuropeptide Release.
1/2021Th2 Modulation of Transient Receptor Potential Channels: An Unmet Therapeutic Intervention for Atopic Dermatitis.
12/2019New Engineered-Botulinum Toxins Inhibit the Release of Pain-Related Mediators.
1/2018A SNAP-25 cleaving chimera of botulinum neurotoxin /A and /E prevents TNFα-induced elevation of the activities of native TRP channels on early postnatal rat dorsal root ganglion neurons.
1/2017A novel therapeutic with two SNAP-25 inactivating proteases shows long-lasting anti-hyperalgesic activity in a rat model of neuropathic pain.
2/2016TNFα induces co-trafficking of TRPV1/TRPA1 in VAMP1-containing vesicles to the plasmalemma via Munc18-1/syntaxin1/SNAP-25 mediated fusion.
10/2014Selective cleavage of SNAREs in sensory neurons unveils protein complexes mediating peptide exocytosis triggered by different stimuli.
9/2014Targeted delivery of a SNARE protease to sensory neurons using a single chain antibody (scFv) against the extracellular domain of P2X(3) inhibits the release of a pain mediator.
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Jiafu Wang Research Topics

Disease

13Pain (Aches)
01/2023 - 08/2007
9Inflammation (Inflammations)
02/2024 - 02/2016
7Atopic Dermatitis (Atopic Eczema)
11/2023 - 11/2019
6Paralysis (Palsy)
01/2017 - 01/2007
5Neoplasms (Cancer)
02/2024 - 08/2015
4Chronic Pain
08/2021 - 04/2009
4Atherosclerosis
12/2014 - 09/2011
3Atrial Fibrillation
05/2024 - 02/2022
3Neuralgia (Stump Neuralgia)
01/2018 - 09/2014
2Atrial Remodeling
05/2024 - 01/2022
2Ventricular Tachycardia
05/2024 - 02/2022
2Migraine Disorders (Migraine)
01/2023 - 08/2007
2Heart Failure
01/2023 - 06/2022
2Neuroinflammatory Diseases
01/2021 - 11/2019
2Necrosis
02/2014 - 05/2009
2Botulism
07/2012 - 02/2011
1Heart Diseases (Heart Disease)
05/2024
1Pruritus (Itching)
02/2024
1Allergic Contact Dermatitis
01/2024
1Hyperalgesia
01/2023
1Edema (Dropsy)
01/2023
1Rheumatoid Arthritis
01/2023
1Disease Resistance
12/2022
1Hypoalbuminemia
06/2022
1Esophageal Neoplasms (Esophageal Cancer)
02/2022
1Hyperplasia
01/2022
1Psoriasis (Pustulosis Palmaris et Plantaris)
01/2022
1Neurogenic Inflammation
11/2021
1Neoplasm Metastasis (Metastasis)
11/2021
1Obesity
10/2021
1Metabolic Syndrome (Dysmetabolic Syndrome X)
10/2021
1Chronic Disease (Chronic Diseases)
12/2019
1Dermatitis
01/2018
1Infections
11/2017

Drug/Important Bio-Agent (IBA)

9Proteins (Proteins, Gene)FDA Link
01/2022 - 01/2007
7CytokinesIBA
01/2023 - 02/2014
7Peptide Hydrolases (Proteases)FDA Link
08/2021 - 05/2012
7incobotulinumtoxinAFDA Link
01/2018 - 02/2011
6SNARE Proteins (SNAREs)IBA
01/2023 - 12/2012
5Botulinum Toxins (Botulinum Toxin)IBA
01/2023 - 12/2011
4Type A Botulinum Toxins (Botox)FDA Link
08/2021 - 02/2011
4Soluble N-Ethylmaleimide-Sensitive Factor Attachment ProteinsIBA
08/2021 - 12/2012
4Peptides (Polypeptides)IBA
10/2014 - 12/2011
3Interleukin-13IBA
11/2023 - 11/2021
3Calcitonin Gene-Related PeptideIBA
01/2023 - 08/2007
3Vesicle-Associated Membrane Protein 3IBA
01/2023 - 02/2014
2Interleukin-6 (Interleukin 6)IBA
01/2023 - 02/2014
2Analgesics (Analgesic Drugs)IBA
08/2021 - 12/2011
2NeuropeptidesIBA
08/2021 - 12/2019
2SodiumIBA
08/2021 - 03/2009
2Transient Receptor Potential ChannelsIBA
08/2021 - 01/2021
2NeurotoxinsIBA
02/2016 - 12/2012
2Propolis (Bee Bread)IBA
08/2013 - 09/2011
2Neurotransmitter Agents (Neurotransmitter)IBA
07/2012 - 02/2011
1AcidsIBA
05/2024
1Biomarkers (Surrogate Marker)IBA
05/2024
1Interleukin-27 (Interleukin 27)IBA
02/2024
1Matrix Metalloproteinase 9 (Gelatinase B)IBA
01/2024
1Toll-Like Receptor 2IBA
01/2024
12,3,4-tri-O-acetylarabinopyranosyl isothiocyanate (AITC)IBA
01/2023
1Nerve Growth Factor (NGF)IBA
01/2023
1Freund's AdjuvantIBA
01/2023
1Sodium-Glucose Transport ProteinsIBA
01/2023
1Tissue Inhibitor of Metalloproteinase-1IBA
01/2023
1STAT6 Transcription FactorIBA
12/2022
1Interleukin-2 (IL2)IBA
12/2022
1Humanized Monoclonal AntibodiesIBA
09/2022
1Interleukin-4 (Interleukin 4)IBA
09/2022
1AlbuminsIBA
06/2022
1Polyvinyl Chloride (PVC)IBA
02/2022
1BariumIBA
02/2022
1Plasminogen Activator Inhibitor 1IBA
01/2022
1interleukin 20 (IL-20)IBA
01/2022
1gallium 68 PSMA-11IBA
11/2021
1Interleukin-13 Receptors (Interleukin 13 Receptor)IBA
11/2021
1lupeolIBA
10/2021
1Blood Glucose (Blood Sugar)IBA
10/2021
1Fatty Acids (Saturated Fatty Acids)IBA
10/2021
1Serotonin ReceptorsIBA
08/2021
1G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA
08/2021
1protachykininIBA
08/2021
1Neuropeptide Y Receptors (Neuropeptide Y Receptor)IBA
08/2021
1Brain Natriuretic Peptide (Natrecor)FDA Link
11/2019
1Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
01/2018
15-nitro-2-(3-phenylpropylamino)benzoic acidIBA
01/2018
1AnkyrinsIBA
01/2018
1AntigensIBA
11/2017
1Attenuated VaccinesIBA
11/2017
12- cyclohexylidenhydrazo- 4- phenyl- thiazoleIBA
06/2017
1CamptothecinIBA
06/2017
1Fluorescent Dyes (Fluorescent Probes)IBA
06/2017
1Pregabalin (Lyrica)FDA Link
01/2017
1Acetylcholine (Acetylcholine Chloride)FDA Link
01/2017
1Phosphotransferases (Kinase)IBA
08/2015
1Oxidized LDL ReceptorsIBA
12/2014
1Class E Scavenger Receptors (Lectin Like Oxidized Low Density Lipoprotein Receptor 1)IBA
12/2014

Therapy/Procedure

8Therapeutics
02/2024 - 04/2009
1Catheter Ablation
05/2024
1Chinese Traditional Medicine (Traditional Chinese Medicine)
02/2024
1Electric Countershock (Cardioversion)
01/2022